gout
Conditions
Interventions
Treatment group:Quzhuo Tongbi Granules+Febuxostat
control group:Chinese herbal placebo+Febuxostat
Sponsors
Zhejiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Meets the 2015 ACR/EULAR diagnostic criteria for gout and is determined to be in a period of intermittent gout; (2) Traditional Chinese medicine syndrome differentiation is for patients with spleen deficiency and dampness obstruction syndrome; (3) Serum urate level = 7mg/dL (420) µ Mol/L); (4) Between the ages of 18 and 80 (including boundary values), regardless of gender; (5) I have not received any uric acid lowering drugs such as allopurinol, benzbromarone, or febuxostat in the past month; (6) Alleviation of joint symptoms in acute gouty arthritis (VAS score 0) for more than 1 week; (7) A history of two or more acute gout attacks in the past year; (8) Voluntarily accept treatment and sign an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Severe liver and kidney dysfunction (AST/ALT more than twice normal, eGFR<60ml/min), hypertension grade I and above, diabetes with target organ damage, severe cardiovascular and cerebrovascular diseases, peptic ulcer with bleeding, perforation and psychosis in the past; (2) Patients who are intolerant or have contraindications to the drugs used in this study (such as uric acid lowering drugs, traditional Chinese medicine, and non steroidal anti-inflammatory drugs); (3) Patients with hyperuricemia caused by bone marrow proliferative disease or other diseases with obvious uric acid excess ("secondary gout"); (4) Pregnant or lactating patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of gout attacks; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of each gout attack (days);Quality of Life;Target rate of uric acid lowering treatment;Randomly assigned to the time span of the first acute exacerbation; | — |
Countries
China
Contacts
Public ContactLin Huang
Zhejiang Chinese Medical University
Outcome results
None listed