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A multicenter self-controlled clinical study of 40Hz blue light flicker based on the "gamma oscillation enhancement" to improve cognitive function in Alzheimer's disease

A multicenter self-controlled clinical study of 40Hz blue light flicker based on the "gamma oscillation enhancement" to improve cognitive function in Alzheimer's disease

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400084416
Enrollment
Unknown
Registered
2024-05-16
Start date
2024-06-01
Completion date
Unknown
Last updated
2024-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer's disease

Interventions

experimental group:blue light flicker

Sponsors

Zhujiang Hospital, Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
55 Years to 100 Years

Inclusion criteria

Inclusion criteria: (1) Age = 55 years old; (2) The Mini Mental State Examination Scale (MMSE) scores 14-24, or the Montreal Cognitive Assessment Scale (MoCA) scores 16-26; (3) Meets the diagnostic criteria for mild cognitive impairment in Alzheimer's disease; (4) Not sensitive to light; (5) The patient has dedicated caregivers who actively cooperate; (6) Agree to accept the treatment method of this study and sign an informed consent form for treatment.

Exclusion criteria

Exclusion criteria: (1) Individuals with severe aphasia, blindness, deafness, and other serious physical illnesses that affect cognitive function; (2) Previous history of epilepsy and family history of mental illness; (3) Previous history of craniocerebral surgery or presence of metal implants in the brain, placement of cardiac pacemakers and ear hearing aids; (4) Any eye disease, such as but not limited to cataracts, glaucoma, retinol (such as macular degeneration), or having undergone major eye surgery; (5) Those who are unwilling to accept this experiment for various reasons or have difficulties completing this experiment.

Design outcomes

Primary

MeasureTime frame
Changes in MMSE scale scores;

Secondary

MeasureTime frame
Changes in MoCA scale scores;MRI brain imaging results;

Countries

China

Contacts

Public ContactWu Wen

Zhujiang Hospital, Southern Medical University

wuwen66@163.com+86 136 1142 7189

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026