Chronic atrophic gastritis
Conditions
Interventions
Experiment group:Qilian Xiaopi prescription
Control group:placebo
Sponsors
Wangjing Hospital of China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Previously HP positive, HP has been successfully eradicated, and the eradication time is more than 1 year; (2) Meet the above criteria for the diagnosis of CAG in Western medicine; (3) Before enrollment, electronic gastroscopy and pathological histology confirmed atrophy (reduction of intrinsic glands) with or without IM, without mild or moderate Dys; (4) Age between 35~70 years old, gender is not limited; (5) Subjects are informed and voluntarily sign the informed consent form; (6) Resident in the local area, able to ensure treatment follow-up, and have a certain reading ability; (7) Those who have not taken anticoagulants such as aspirin and warfarin and those who have no coagulation dysfunction.
Exclusion criteria
Exclusion criteria: (1) Autoimmune gastritis (chronic atrophic gastritis type A); (2) Patients with gastric and duodenal ulcers and upper gastrointestinal bleeding; (3) Patients with high-grade intraepithelial neoplasia of the gastric mucosa or suspected malignant transformation by pathological diagnosis; (4) Patients with serious primary diseases such as heart, brain, liver, kidney, lung and blood system; (5) Suffering from mental illness; (6) Pregnant or lactating women (female subjects must use contraception); (7) Those with allergies or a history of allergies to multiple drugs (more than two or known drugs or ingredients in the study); (8) Other circumstances that the investigator considers inappropriate for inclusion; (9) Patients who are participating in clinical trials of other drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement rate of OLGA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement rate of OLGIM ;Improvement rate of gastric mucosal gland atrophy ;TCM syndrome evaluation index;Improvement rate of gastric mucosal intestinal metaplasia ; | — |
Countries
China
Contacts
Public ContactWei Wei
Wangjing Hospital of China Academy of Chinese Medical Sciences
Outcome results
None listed