Patients with brain tumor, meningioma and hemangioma
Conditions
Interventions
Experimental groups:Continuous infusion of norepinephrine combined with GDHT regimen
control groups:bolus of norepinephrine combined with GDHT regimen
Sponsors
the First Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients who are selected to undergo resection of brain tumor, meningioma and hemangioma. 2. Surgical duration>3 hours. 3. Patients aged>18 years old. 4. The patient is able to understand the written informed consent document and has the willingness to sign it.
Exclusion criteria
Exclusion criteria: 1. Patients with tumors located in the brainstem and deep brain stem. 2. Patients aged = 18 years old 3. Patients with ASA grading>Level III 4. Patients with a body mass index (BMI) greater than 30 kg/m2 or less than 15 kg/m2 5. Patients with preoperative arrhythmia or newly developed arrhythmia after anesthesia induction. 6. Patients with moderate to severe heart valve disease. 7. Patients with preoperative ventricular dysfunction (left ventricular ejection fraction<40%, right ventricular dysfunction, intracardiac shunt). 8. Patients with preoperative hemodynamic instability. 9. Patients with preoperative sepsis. 10.Patients with chronic kidney disease and a glomerular filtration rate of<30 ml/min/1.73m^2 or requiring renal replacement therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| systemic inflammatory response syndrome (SIRS) and dysfunction of at least one major organ system; | — |
Secondary
| Measure | Time frame |
|---|---|
| liquid intake and outflow;Time spent in the ICU; | — |
Countries
China
Contacts
Public ContactKe An
the First Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed