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Clinical and mechanistic studies on transcutaneous auricular vagus nerve stimulation for postoperative delirium

Clinical and mechanistic studies on transcutaneous auricular vagus nerve stimulation for postoperative delirium

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400084323
Enrollment
Unknown
Registered
2024-05-14
Start date
2024-06-06
Completion date
Unknown
Last updated
2024-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative delirium

Interventions

taVNS:The patients in the experimental group were stimulated with transcutaneous auricular vagus nerve stimulation, and the stimulation mode was electrode placed on the left ear nail boat, the stimula
Sham taVNS:In the control group, the stimulating electrodes were placed on the corresponding site, and the instrument was turned on to give a short stimulation for 30s. After that, the instrument was

Sponsors

Baoding NO.1 Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for hip surgery; 2. Aged 65 years and older; 3. Patients with preoperative American Society of anesthesiologists (ASA) grading of I ~ III; 4. The anesthesia method is intravenous inhalation combined anesthesia.

Exclusion criteria

Exclusion criteria: 1. Refuse to sign informed consent or unable to undergo various assessments; 2. History of psychiatric illness (excluding anxiety and depression) or psychotropic medication use within one month; 3. History of transcranial and percutaneous stimulation; 4. History of earnail injury or allergies; 5. In vivo implantation of electronic devices (e.g. pacemakers); 6. History of abuse of opioids or other drugs; 7. Re-surgery within a short period (within 5 days); 8. Vulnerable groups, including patients with mental illness, cognitive impairment, severe illness, illiterates, etc..

Design outcomes

Primary

MeasureTime frame
Postoperative delirium(POD) incidence;

Secondary

MeasureTime frame
Severity of POD;Delirium subtypes;Anxiety;Depression;pain;Postoperative sleep quality;Postoperative recovery quality;postoperative complications;

Countries

China

Contacts

Public ContactChunguang Wang

Baoding NO.1 Central Hospital

18617789771@163.com+86 186 1778 9771

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026