Bipolar disorder, schizophrenia, and major depressive disorder
Conditions
Interventions
THRIVE group:The Optiflow THRIVE (Fisher & Paykel Healthcare, Auckland, New Zealand) is a humidifier with an integrated flow generator that delivers high-flow, warmed, and humidified oxygen at up to 7
Facemask group:In the facemask group, preoxygenation with 100% oxygen was carried out for 3 minutes at a rate of 10 L/min, with no positive airway pressure applied, using an appropriately sized mask.
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) adult psychiatric patients (aged 18–65 years) who had been diagnosed with schizophrenia, BD, or MDD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V); (2) patients with American Society of Anesthesiologists (ASA) physical status I-II; (3) patients with a BMI between 18.5 and 23.9 kg/m2 due to the risk of desaturation associated with a higher BMI; (4) patients who were able to receive THRIVE technique following instructions properly.
Exclusion criteria
Exclusion criteria: (1) the presence of other psychiatric disorders as defined by DSM-IV, such as alcohol or substance use disorder; (2) those suffering from obstructive sleep apnea syndrome (OSAS) along with nasopharyngeal abnormalities, epistaxis, or a history of nasal surgery; (3) known or anticipated airway obstruction requiring intubation; (4) patients suffering from severe or unstable somatic conditions, such as chronic obstructive pulmonary disease (COPD) or emphysema; (5) pregnant or nursing women; (6) contraindications to ECT or anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The lowest SpO2 levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of oxygen desaturation;EEG seizure duration;stimulation dosage;vital signs (including average SpO2 levels, HR, and MAP); | — |
Countries
China
Contacts
Public ContactSha Nie
The Affiliated Brain Hospital of Guangzhou Medical University
Outcome results
None listed