Complex pleural effusion
Conditions
Interventions
Group A:Given 200ml of normal saline daily by intrathoracic injection
Group B:Given 200ml of 2.5% sodium bicarbonate daily by intrathoracic injection (5% sodium bicarbonate 1:1 with normal saline).
Sponsors
The First Affiliated Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Hospitalized patients aged 18-80 years (including 18 and 80 years). 2) Meet any of the three criteria for complex pleural effusion: A.PH 1000IU/L; C. pleural fluid etiological culture or smear positive. 3) Patients with pleural effusion >300ml (calculated according to CT pleural effusion image range D2*L, D maximum depth, L maximum length) and it is necessary to perform pleural effusion drainage according to clinical guidelines or standards.
Exclusion criteria
Exclusion criteria: 1) The causes of pleural effusion were hospital-acquired disturbance, tuberculous pleural effusion, fungal infection-associated pleural effusion, or non-infectious pleural effusion 2) Inability to tolerate intrathoracic administration or allergy to sodium bicarbonate 3) There is contraindication of thoracentesis catheterization for coagulation dysfunction 4) The combination of other chronic lung diseases may lead to poor antibiotic treatment and interfere with outcome judgment (e.g., uncontrolled COPD (GOLD E group), bronchiectasis, immune deficiency) or long-term use of glucocorticoids due to chronic disease 5) Concurrent shock, massive bleeding, major trauma or lung surgery within the last 5 days 6) A history of lung or pleural surgery on the pleural effusion side 7) Patients who have recently undergone thoracic catheterization due to pneumothorax or surgery or pleural effusion 8) Pregnant or lactating women 9) Patients who are currently participating in a clinical trial of any other drug or device 10) Patients with poor compliance are either difficult to follow up or can expect to survive less than 3 months due to diseases other than pleural effusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Surgical referral rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of hospital stay;Change rate of pleural thickness before and after treatment;All-cause mortality;WBC;neutrophilic granulocyte percentage;CRP;PCT;IL-6;The amount of pleural fluid; | — |
Countries
China
Contacts
Public ContactCao Chao
The First Affiliated Hospital of Ningbo University
Outcome results
None listed