Obstructive Sleep Apnea
Conditions
Interventions
Phase 1 team:Dexmedetomidine bolus+ tetracaine atomization inhalation
Phase 2 team:Dexmedetomidine maintenance dose
Sponsors
University of Science and Technology of China,Anhui Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients with obstructive sleep apnea who are scheduled to undergo endoscopic sleep surgery 2. Age range: 18-65 years old 3. ASA grade: < IV 4. Able to communicate, willing to sign an informed consent form, and willing to comply with the requirements of the trial protocol.
Exclusion criteria
Exclusion criteria: 1. Patients who refuse to undergo drug-induced sleep endoscopy 2. Patients with a history of allergy or specific reaction to amide local anesthetics 3. Patients with a history of abuse of sedative-hypnotic drugs 4. Patients allergic to dexmedetomidine, with preoperative hypotension, bradycardia, severe heart block, and severe ventricular dysfunction 5. Morbidly obese patients (BMI = 35 kg/m^2) 6. Patients with severe cardiac, pulmonary, or renal insufficiency, combined with multiple chronic diseases who cannot tolerate surgical anesthesia 7. Patients with uncontrolled hypertension or diabetes 8. Patients with a history of neurological diseases, who cannot communicate normally, and patients with mental illness 9. Other situations deemed unsuitable for inclusion by the researcher
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EC50;EC90; | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical response;bispectral index, BIS;snoring; | — |
Countries
China
Contacts
Public ContactLizhen Wang
The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine, University of Science and Technology of China
Outcome results
None listed