Postoperative delirium
Conditions
Interventions
Control group :Observe the rate of postoperative delirium in patients
Preoperative chemotherapy group:Observe the rate of postoperative delirium in patients
Sponsors
Department of Anesthesiology, Fudan University Shanghai Cancer Center
Eligibility
Sex/Gender
All
Age
60 Years to 95 Years
Inclusion criteria
Inclusion criteria: 1) Patients who signed an informed consent form and were willing to complete the study according to the protocol; 2) Age = 60 years old; (3) Tumor TNM stage T2~T3, N0~N2, American Society of Anesthesiologists (ASA) grade I~III; (4) The patients' preoperative blood and urine routine, liver and kidney functions, and blood electrolytes were all in normal range;
Exclusion criteria
Exclusion criteria: 1) Refusal of enrollment; 2) A clear preoperative history of neurologic and psychiatric disorders or long-term use of sedatives or antidepressants; 3) A history of alcoholism or drug dependence; 4) Having severe visual or hearing impairment; 5) A history of hemorrhagic or embolic cerebrovascular disease; 6) Inability to cooperate in completing cognitive function tests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium rate;Serum inflammatory factors: IL-6, TNF-a levels;Serum markers of nerve injury: levels of S100ß, NSE; | — |
Secondary
| Measure | Time frame |
|---|---|
| Extraction time;PACU awakening time;Days of hospitalization; | — |
Countries
China
Contacts
Public ContactZhang jun
Department of Anesthesiology, Fudan University Shanghai Cancer Center
Outcome results
None listed