A prospective study of the association between endothelial glycocalyx damage and cognitive dysfunction in patients undergoing cardiac surgery.

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400084294

Enrollment

Unknown

Registered

2024-05-14

Start date

2024-05-20

Completion date

Unknown

Last updated

2024-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative cognitive dysfunction

Interventions

Observation group:None

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age=18 Planning elective cardiac surgery (coronary artery bypass grafting and/or heart valve); The score of the simple mental state scale assessed before surgery was greater than the lowest score of the corresponding educational level: illiteracy =17 points, primary education = 20 points, and middle school and above =23 points; Able to complete neuropsychological tests.

Exclusion criteria

Exclusion criteria: Cognitive dysfunction existed before operation. Diagnosis of mental and neurological disorders; History of craniocerebral trauma; History of stroke or intracranial hemorrhage.

Design outcomes

Primary

Measure	Time frame
Postoperative cognitive dysfunction;glycocalyx;	—

Secondary

Measure	Time frame
Inflammatory index;regional cerebral oxygen saturation;Cerebral metabolic index;	—

Countries

China

Contacts

Public ContactWangWeijian

The First Affiliated Hospital of Wenzhou Medical University

wangwj2002@hotmail.com+86 138 0668 3232

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026