Effect of transcutaneous auricular vagus nerve stimulation on postoperative delirium in elderly patients undergoing spinal surgery: A randomized controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400084277

Enrollment

Unknown

Registered

2024-05-14

Start date

2024-05-20

Completion date

Unknown

Last updated

2024-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative delirium

Interventions

SS group:Sham transcutaneous auricular vagus nerve stimulation

taVNS group:Transcutaneous auricular vagus nerve stimulation

Eligibility

Sex/Gender

All

Age

65 Years to No maximum

Inclusion criteria

Inclusion criteria: ? Age =65 years old, both sexes; ? patients scheduled for elective spinal surgery; ? BMI 18 <BMI <30; ?ASA grade I-III.

Exclusion criteria

Exclusion criteria: ? preoperative comorbid epilepsy, Parkinson's disease, Alzheimer's disease, schizophrenia and other neurological or psychiatric diseases; ? Severe hearing or visual impairment; ? preoperative mini-mental State examination (MMSE) score < 24; ? recent use of cholinergic or anticholinergic drugs; ? body mass index =30; ? Skin infection, damage, or scar on the ear.

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative delirium;	—

Secondary

Measure	Time frame
Postoperative pain score;Postoperative sleep quality;Interleukin-6 level in peripheral blood;Interleukin-1ß level in peripheral blood;	—

Countries

China

Contacts

Public ContactLong Sun

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

sun_long2@163.com+86 131 6282 9721

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026