Sleep-wake disorder
Conditions
Interventions
Esketamine group:After induction of anesthesia, esketamine 1mg/ (kg·h) (concentration 1mg/ml) was administered intravenously for 30min.
Control group :After induction of anesthesia, the same volume of 0.9% normal saline was injected intravenously for 30 min.
Sponsors
Women's Hospital School of Medicine Zhejiang University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age 18-65 years old; ASA I-II level; Patients undergoing gynecological laparoscopic surgery; The operation lasts longer than 1 hour.
Exclusion criteria
Exclusion criteria: Patients refused to participate in the study; Body mass index (BMI) greater than 30; There is a clear history of mental sleep problems in the past (depression, schizophrenia, sleep disorders, PSQI > 7 score 18) or a family history of sleep problems in three generations of the second line; Cognitive or communication impairment; A recent history of substance abuse; Contraindications or esketamine allergy; Cognitive impairment or inability to communicate; This study must be approved by the Ethics Committee of the hospital, and all patients participating in the study must sign the informed consent of anesthesia and experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of sleep disturbance on the first day after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Eeg spectral values;Electroencephalogram Index;Incidence of sleep disturbance;Numeric rating scale of sleep;Pittsburgh Sleep Quality Index score;Insomnia Severity Index score;Self-Rating Anxiety Scale score; | — |
Countries
China
Contacts
Public ContactLili Xu
Women's Hospital School of Medicine Zhejiang University
Outcome results
None listed