Perioperative anaphylaxis
Conditions
Interventions
Gold Standard:Skin test and/or basophil activation test
Index test:Passive mast cell activation test
Sponsors
China-japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with PA may exhibit various clinical manifestations within 15 minutes after the administration of anesthetic drugs during the perioperative period. These manifestations include: 1.Circulatory system: hypotension (systolic blood pressure = 70 mmHg), tachycardia (heart rate = 110 beats/min), or rapid progression to serious arrhythmia, circulatory failure, or cardiac arrest.; 2.Respiratory system: increased secretion of saliva and sputum, laryngospasm, bronchospasm, increased airway pressure (peak airway pressure = 40 mmHg), wheezing, moist rales in the lungs, and hypoxemia (SpO2 = 90%); 3.Digestive system: nausea, vomiting or diarrhea; 4.Skin and mucosa: skin flushing, various rashes (especially wind blot-like papules), subcutaneous angioedema, systemic skin edema, and edema of nasal, eye, and throat mucosa;
Exclusion criteria
Exclusion criteria: 1.Cases with systemic manifestations meeting the inclusion criteria but failing to make differential diagnosis from non-allergic diseases such as asthma attack, hemorrhagic shock, deep anesthesia, or pulmonary embolism. 2.Patients who are unable to discontinue antihistamines or glucocorticoids when BAT or pMAT are needed, as they may affect results; 3.Patients with severe immune system diseases, hematological system diseases, or skin diseases that could impact the allergen detection results; 4.Anaphylaxis occurring within 4-6 weeks prior to participating in the trial; 5.Patients who decline to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of mast cells activated; | — |
Secondary
| Measure | Time frame |
|---|---|
| Accuracy;sensitivity;false negative rate;Area under ROC curve; | — |
Countries
China
Contacts
Public ContactZhao Jing
China-japan Friendship Hospital
Outcome results
None listed