muscle relaxant
Conditions
Interventions
Lidocain group:Before induction of anesthesia,lidocaine was injected intravenously at 1.5mg/kg,then lidocain 2 mg/ (kg·h) was administered intravenously for 30 minutes.
Control group :Before induction of anesthesia, 0.9% normal saline is injected intravenously at the same volume,then the same volume of 0.9% normal saline was administered intravenously for 30 minute
Sponsors
Women's Hospital School of Medicine Zhejiang University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: ? 18-65 years; ? BMI: 18.5-24.9 kg/m2; ? ASA classification: I-II; ? undergoing gynecological laparoscopic surgery under general anesthesia; ? neuromuscular monitoring allowed on one side of the forearm and hand in all surgical positions.
Exclusion criteria
Exclusion criteria: ? Mallampati classification =III indicating difficult airway; ? history of allergy to lidocaine, rocuronium, or similar anesthetic drugs; ? history of long-term sedative drug use; ? preoperative ECG indicating bradycardia; ? preexisting chronic diseases such as hypertension, diabetes, heart disease, chronic pulmonary disease, asthma, neuromuscular diseases, etc.; ? abnormal liver or kidney function; ? acute infection; ? obstructive sleep apnea syndrome (OSAS).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Onset time of muscle relaxant; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nonreactive period;Clinical duration;Recovery index;Cooper's tracheal intubation condition score;Numerical pain intensity scale (NRS) ;The Ramsay sedation scale;Dosage of mivacurium;Extubation time; | — |
Countries
China
Contacts
Public ContactLili Xu
Women's Hospital School of Medicine Zhejiang University
Outcome results
None listed