Chronic kidney disease stage 3-5 (CKD3-5)
Conditions
Interventions
Sponsors
Wangjing Hospital, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) aged 18-85 years old; (2) TCM syndrome differentiation was in accordance with the TCM diagnostic criteria of "spleen and kidney deficiency, blood stasis turbidity and poison syndrome"; (3) meet the diagnostic criteria of western medicine and eGFR=60 mL/min/1.73m2 (CKD3-5 stage); (4) The patient did not receive renal replacement therapy; (5) Informed consent was signed voluntarily.
Exclusion criteria
Exclusion criteria: (1) Previous history of acute cardiovascular and cerebrovascular diseases in the past six months; (2) renal replacement therapy such as blood purification and kidney transplantation has been performed; (3) Critical condition, unstable vital signs and emergency dialysis indications; (4) patients currently taking corticosteroids or immunosuppressants; (5) complicated with other serious diseases, such as chronic liver cirrhosis, hematological diseases, malignant tumors, etc.; (6) there are serious psychological or mental abnormalities; (7) pregnant or lactating women; (8) Allergic constitution, or allergic to multiple drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum creatinine;Estimated glomerular filtration rate;Kauppila calcification score;Carotid intima-media thickness values;Valve calcification values; | — |
Secondary
| Measure | Time frame |
|---|---|
| Transforming growth factor ß1;Type IV collagen;Indoxyl sulfate;Indole-3-acetic acid;P-cresol sulfate;Trimethylamine oxide;Intact parathyroid hormone;Total serum calcium;Serum phosphorus;Calcium and phosphorus product;Bone-specific alkaline phosphatase;Symptom Score;Traditional Chinese medicine, Symptom, Efficacy;Renal function, Efficacy; | — |
Countries
China
Contacts
Public ContactTongxia Li
Wangjing Hospital, China Academy of Chinese Medical Sciences
Outcome results
None listed