Parkinson's disease
Conditions
Interventions
treat group:? The first week of intervention: Take type II high-protein rice fiber powder, once a day (1 bag/time, 20g/ bag), directly add warm water and eat, or add milk, porridge and other foods tog
Sponsors
the Affiliated Hospital of Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: ?Male or female aged 55 to 75 years; ? Han people in Zhejiang province, non-vegetarians; ? Be willing to complete questionnaires and records related to the study, and provide blood and stool samples; ? It meets the diagnostic criteria for primary PD published by MDS in 2015, and the Hoehn& Yahr classification is stage 2 to 3.
Exclusion criteria
Exclusion criteria: ? Patients with Parkinson's combined syndrome and secondary Parkinson's syndrome; ? Obvious history of mental illness; ? Have taken antibiotics or probiotics, prebiotics, dietary fiber supplements in the past 1 month; ? Have a long history of going out in the past six months (>5 days); ? Cancer, cardiovascular and digestive diseases (peptic ulcer, IBD, IBS), autoimmune diseases. ?Blood routine, liver and kidney function examination found serious abnormalities ?Addiction to tobacco and alcohol (abuse) ? Taking medication for constipation or diarrhea (such as lactulose) ? Obesity (BMI>30) ? Food allergies or dietary restrictions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in fecal flora composition and metabolism (especially short-chain fatty acid SCFA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse event occurrence rate; | — |
Countries
China
Contacts
Public ContactHu zhengxiang
the Affiliated Hospital of Hangzhou Normal University
Outcome results
None listed