Acute Ischemic Stroke
Conditions
Interventions
Experimental group:Combination therapy of conventional medication with plasma adsorption therapy
Control group:Conventional drug therapy
Sponsors
The Fifth Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1: Age = 18 years; 2: Clinically confirmed first-ever acute ischemic stroke, meeting the diagnostic criteria of the "Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018"; 3: Onset within 72 hours; 4: NIHSS score of 4-22 points; 5: Pre-stroke mRS score = 1 point; 6: Patients with elevated inflammatory factors; 7: Willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1: Patients receiving thrombolytic therapy and/or interventional treatment; 2: Patients with active bleeding or severe bleeding tendencies; 3: Coagulation disorders; 4: Patients with infections, with axillary or ear temperature = 37.5°C; 5: Patients with tumors; 6: Patients with immune system disorders; 7: Pregnant or lactating women; 8: Patients with other conditions that prevent them from undergoing relevant blood purification treatment (such as moderate to severe anemia, hypotension, inability to meet puncture requirements) or those who cannot effectively cooperate; 9: Patients allergic to study drugs or medical devices (extracorporeal circulation, blood perfusion devices); 10: Other conditions judged by the investigator as unsuitable for inclusion; 11: Patients receiving treatment with drugs such as alteplase.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with 90-day mRS Score 0-2; | — |
Secondary
| Measure | Time frame |
|---|---|
| inflammatory factors;0-day cognitive function score MMSE, MoCA; | — |
Countries
China
Contacts
Public ContactLei zhang
The Fifth Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed