Patients undergoing elective Trendelenburg position gynecological laparoscopic surgery
Conditions
Interventions
Group D:Continuously administer 5 Vol% desflurane inhalation for maintenance, and downregulate the plasma target concentration of propofol to 1.0 µ Continuous pumping in g/ml
Group T:Set the plasma target concentration of propofol to 2.0 µ Pump in g/ml
Sponsors
Women 's Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital
Eligibility
Sex/Gender
Female
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients undergoing gynecological laparoscopic surgery in the Trendelenburg position, with an American Society of Anesthesiologists (ASA) I-II rating, aged 45-65 years, 1 hour = surgery time = 3 hours.
Exclusion criteria
Exclusion criteria: 1. Severe cognitive impairment before surgery; 2. Epilepsy, hemiplegia, aphasia, and other cerebrovascular diseases; 3. Severe infection, dehydration, electrolyte disorders, and shock; 4. Severe cardiopulmonary (NYHA grade = 3, COPD), liver and kidney dysfunction (Child · Pugh grades B and C, creatinine>200umol/L); 5. Hemoglobin concentration<10mgdl-1; 6. Pregnancy status; 7. History of allergy to anesthetic drugs; 8. Have participated in other clinical trials within the first three months of enrollment and are currently participating in other clinical trials; 9. According to the judgment of the physician in charge of the trial, the implementation of the trial may increase the risk of the subjects, or patients may not be able to obtain sufficient trial data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| regional cerebral oxygen saturation;MMSE;MoCA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood presure;PaO2;PaCO2; | — |
Countries
China
Contacts
Public ContactZhang Huiying
Women 's Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital
Outcome results
None listed