Effects of sodium bicarbonate Ringer's solution combined with positive end-expiratory pressure ventilation on the internal environment of patients undergoing bariatric surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400084165

Enrollment

Unknown

Registered

2024-05-11

Start date

2024-05-17

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic disease

Interventions

C:Compound sodium chloride solution without PEEP

P:Compound sodium chloride solution with PEEP

B:Sodium bicarbonate Ringer's solution without PEEP

B+P:Sodium bicarbonate Ringer's solution with PEEP

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) Patients who intend to undergo laparoscopic weight loss surgery (2) BMI=30 kg/? (3) ASA II-III level (4) 18-65 years old, age is not limited

Exclusion criteria

Exclusion criteria: (1) Patients with serious heart, brain, lung, liver, kidney and metabolic diseases (2) Patients with pulmonary bulla and emphysema (3) Patients with sleep apnea syndrome (OSAS) (4) Patients with a history of lung surgery or upper abdominal surgery (5) Refuse to accept the signed informed consent

Design outcomes

Primary

Measure	Time frame
Arterial blood gas analysis;	—

Secondary

Measure	Time frame
TNF-a;IL-6;IL-10;QoR-15;Incidence of postoperative nausea and vomiting;Postoperative VAS score;Intraoperative infusion volume;awakening time;Recovery room residence time;Total hospital stay;blood pressure;blood pressure;SpO2;mean arterial pressure;PetCO2;airway pressure;	—

Countries

China

Contacts

Public ContactZhiping Wang

Affiliated Hospital of Xuzhou Medical University

zhpsqxt@126.com+86 133 3878 7071

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026