Study on the effects of S-ketamine on the immune microenvironment in perioperative patients

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400084159

Enrollment

Unknown

Registered

2024-05-11

Start date

2023-09-11

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cervical cancer

Interventions

Group S:S-ketamine

Group C:Saline

Eligibility

Sex/Gender

All

Age

40 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. The cervical cancer patients undergoing selective abdominal total hysterectomy. All the included experimental subjects signed a written informed consent form; 2. Age 40-65 years old; 3. American Society of Anesthesiologists ASA classification I to II;

Exclusion criteria

Exclusion criteria: 1. Patients with a history of allergy to related anesthetics; 2. Patients refused to cooperate; 3. Severe cardiopulmonary disease or craniocerebral injury or mental illness; 4. Uncontroled hypertensive patients.

Design outcomes

Primary

Measure	Time frame
PD1-PDL1 alteration;CTCs alteration;Alteration of Circ-HIPK3-miR-338-3p-PAK1-mapk pathway;	—

Secondary

Measure	Time frame
postoperative pain;	—

Countries

China

Contacts

Public ContactZhongyun Wang

the First Affiliated Hospital of Nanjing Medical University

zywang1970@126.com+86 139 1391 6609

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026