Gynecological malignant tumor
Conditions
Interventions
K group:Esketamine 0.5mg/kg was injected intravenously before skin incision.
C group:Inject the same dose of saline before skin incision.
Sponsors
Xing' an league people's hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-65 years; (2) It is planned to perform elective gynecological laparoscopic radical resection of malignant tumor under general anesthesia; (3) The 3)ASA score is ? ~ ?; (4) The estimated survival time is more than 3 months; (5) Voluntary signing of informed consent.
Exclusion criteria
Exclusion criteria: (1) patients who are expected to enter ICU after operation; (2) Patients who are allergic to Esketamine Injection; (3) Patients with mental system diseases, severe consciousness disorders and cognitive dysfunction; (4) Have a serious cardiovascular history: congestive heart failure, severe angina pectoris, unstable angina pectoris or myocardial infarction within 6 months; (5) Pregnant or lactating patients; (6) Patients with 6)MMSE score < 18; (7) Patients with any of the following contraindications to the use of Esketamine Injection: (1) Patients with severe blood pressure or increased intracranial pressure risk; 2) Patients with high intraocular pressure (glaucoma) or penetrating ocular trauma; 3) poorly controlled or untreated hypertension (resting systolic blood pressure exceeds 180mmHg or diastolic blood pressure exceeds 100 mmHg); 4) Patients with hyperthyroidism; 5) Preeclampsia and eclampsia; 6) Use it when a uterine relaxant is needed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS pain score was evaluated within 48 hours after operation.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of laryngeal mask removal;Get out of bed activity time;First exhaust time; | — |
Countries
People's Republic of China
Contacts
Public ContactRenjie
Xing' an league people's hospital
Outcome results
None listed