Alzheimer 's disease patients with dysphagia
Conditions
Interventions
Control group:oropharyngeal sensory training, oral exercise training, tongue exercise training, Mendelssohn training, head and neck training
Test team:On the basis of training in the control group, transcutaneous auricular vagus nerve electrical stimulation was performed.
Sponsors
Zhejiang Provincial People 's Hospital
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: AD conforms to the relevant diagnostic criteria in ' Neurology ( 8th edition ) ', and the severity of the disease is in the mild to moderate stage ; 2 TCM diagnosis refers to the ' Guiding Principles for Clinical Research of New Drugs of Traditional Chinese Medicine ', and the syndrome differentiation is phlegm and blood stasis syndrome. The main symptoms are slow response, mental decline, and forgetfulness. Secondary symptoms : tinnitus and deafness, dizziness, chest tightness, shortness of breath, sticky mouth, dark complexion ; dark purple tongue with ecchymosis, greasy fur or less fur, deep fine or astringent pulse ; the main symptoms combined with any two secondary symptoms can be diagnosed ; 3 aged 55-80 years old ; 4 can cooperate with swallowing function examination and questionnaire survey ; 5 The existence of oropharyngeal dysphagia was confirmed by swallowing angiography ; 6 not taking antipsychotic drugs.
Exclusion criteria
Exclusion criteria: 1 Dementia caused by cerebrovascular disease, Parkinson 's disease and hypothyroidism ; 2 Clinical Dementia Rating ( CDR ) = 3 ] ; 3 patients with obstructive pulmonary disease, pulmonary infection and other factors affecting blood oxygen saturation ; 4 oropharyngeal, esophageal organic lesions, or stroke, Parkinson 's disease, multiple sclerosis, myasthenia gravis, metabolic myopathy and other neurological diseases that may affect swallowing ; 5 patients with severe visual or hearing impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the scores of Standardized Swallowing Assessment , SSA;Swallowing related physiological parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Leakage aspiration grading;Quality of life in patients with dysphagia;transscranial magnetic stimulation-motor evoked potential; | — |
Countries
China
Contacts
Public ContactLu-Lu,Tong
Zhejiang Provincial People 's Hospital
Outcome results
None listed