allergic rhinitis
Conditions
Interventions
Sponsors
Beijing No.1 Biochemical Pharmaceutical Co., Ltd.
Eligibility
Sex/Gender
All
Age
4 Years to 12 Years
Inclusion criteria
Inclusion criteria: (1) Had a history of seasonal allergic rhinitis (hay fever) and was enrolled before the pollen spread of the season, that is, before the onset of symptoms; (2) Age 4-12 years old, male or female; (3) Subjects = 5 years of age < 12 years of age with a history of at least two years of seasonal allergic rhinitis, with or without conjunctivitis; Subjects = 4 years old and < 5 years old had a history of at least one year of seasonal allergic rhinitis with or without conjunctivitis (consultation), with seasonal exacerbation; (4) Meet the diagnostic criteria for allergic rhinitis, referring to the Guidelines for the Diagnosis and Treatment of allergic rhinitis (revised 2022); (5) Rhinitis symptom score =4 points among the four rhinitis symptoms (nasal itching, nasal congestion, sneezing and runny nose) (symptom score of the last pollen season was collected after consultation); (6) Seasonal pollen serum specific IgE above grade 2 or skin prick ++; (7) Voluntary test and signed informed consent; (8) Patients who have not received other allergy drugs or other classes of immunomodulatory drugs within 4 weeks.
Exclusion criteria
Exclusion criteria: (1) After physical examination, nasal polyps were found, and obvious nasal structure abnormalities were easy to cause ventilation Those with abnormal functions; (2) Obvious snoring accompanied by adenoid hypertrophy and/or tonsil fat during the screening evaluation period Large (consultation); (3) Past and present patients with interstitial lung disease, muscular dystrophy, congenital immune deficiency Malignant tumors, autoimmune diseases, airway dysplasia and other major diseases; (4) Patients with oral disease, heart disease, chronic kidney disease and gastric ulcer during the screening and evaluation period (to diagnose); (5) Patients with perennial rhinitis (consultation); (6) Screening evaluation in the last pollen season, the onset of rhinitis does not require oral antihistamines or nasal treatment Those who can relieve themselves by spraying hormone (consultation); (7) Previous history of asthma; (8) Systemic use of glucocorticoids within four weeks prior to medication; (9) Participants in other clinical trials within three months; (10) Any other circumstances in which the investigator deems it inappropriate to participate in the trial. Note: Consultation information is only judged by consultation results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptom score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total drug score;Quality of life score;Blood routine examination;Determination of cytokines in peripheral blood; | — |
Countries
China
Contacts
Public ContactWang Xiaoyue
The First Affiliated Hospital of Baotou Medical College
Outcome results
None listed