liver failure complicated with acute kidney injury
Conditions
Interventions
Regional citrate anticoagulation:Patients appling regional citrate anticoagulation during CRRT
traditional anticoagulation:Patients appling traditional anticoagulation during CRRT
Sponsors
The First Affiliated Hospital of the Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age =18 years old; 2.liver failure: Acute liver failure (including chronic acute): hepatic coma (if the patient has other causes related to impaired consciousness, a comprehensive judgment can be made based on test indicators), PTA (prothrombin activity) 85.5 micromol/L (or daily increase = 17.1 micromol/L); Chronic liver failure: Child-Pugh score =10, or INR >1.5 (no anticoagulation), or PTA (prothrombin activity) 51 micromol/L (3 times the upper limit of normal); 3.Have an indication for CRRT treatment and are willing to accept CRRT treatment; 4.Willing to participate in this study and sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. Non-renal replacement therapy reasons require systemic anticoagulation (heparin/low molecular/warfarin, etc.); 2. Patients who are pregnant or breastfeeding; 3. Uncorrectable lactic acidosis (pH 2 hours, and lactate >8mmol/L); 4. Patients treated with CRRT for internal fistula; 5. Pre-existing heparin-induced thrombocytopenia; 6. Known allergy to a certain anticoagulant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| patients survival time;filter lifespan; | — |
Secondary
| Measure | Time frame |
|---|---|
| bleeding;Kidney recovery;Filter transmembrane pressure;CRRT-related complications; | — |
Countries
China
Contacts
Public ContactShiren Sun
The First Affiliated Hospital of the Air Force Medical University
Outcome results
None listed