permeability pulmonary edema
Conditions
Interventions
observation:The patient was ventilated in prone position during mechanical ventilation
Control:No intervention
Sponsors
The First Affiliated Hospital of Xiamen University, ICU
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Aged =18 years old, male or female; (2) Diagnosis of permeability pulmonary edema with the following characteristics: hypoxemia (PaO2/FiO2<300 mmHg), reduced lung compliance (<50 mL/cmH2O), chest X-ray or CT showing diffuse lung sexual infiltration shadow; (3) Receive mechanical ventilation treatment, and the ventilation mode is volume control or pressure control; (4) Use the PiCCO system to monitor hemodynamic parameters within 2 hours before enrollment; (5) Sign the informed consent form, or have it signed by its legal representative.
Exclusion criteria
Exclusion criteria: (1) There is cardiogenic pulmonary edema or other types of pulmonary edema; (2) There are heart diseases such as valvular heart disease, cardiomyopathy, pericarditis, cardiac tamponade, and atrial fibrillation; (3) There are pulmonary vascular diseases such as pulmonary embolism, pulmonary hypertension, pulmonary arteriovenous fistula, and post-pneumonectomy; (4) There are large vascular diseases such as aortic aneurysm, aortic dissection, aortic stenosis; (5) There are systemic diseases such as severe liver insufficiency, renal insufficiency, and coagulation dysfunction; (6) There are life-threatening conditions such as severe septic shock, multiple organ failure, intracranial hypertension; (7) There are contraindications to the PiCCO system, such as aneurysm, arteriosclerosis, arterial stenosis, arterial embolism, arteritis, arterial puncture site infection, etc.; (8) Refusing to participate in this study or unable to comply with the requirements of the research protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Power of respiratory machinery ;Extravascular lung water volume; | — |
Secondary
| Measure | Time frame |
|---|---|
| PaO2;PETCO2;HR;NLRP3;Duration of mechanical ventilation; | — |
Countries
China
Contacts
Public ContactXu Hao
The First Affiliated Hospital of Xiamen University ICU
Outcome results
None listed