chronic heart failure
Conditions
Interventions
experiment group:Kan Li granule
control group:conventional treatment
Sponsors
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) age 18-75 years old; (2) patients meet the diagnostic criteria of CHF (NYHA grade II-IV); (3) patients received a steady dose of conventional heart failure medications, including angiotensin converting enzyme inhibitors (ACEI), beta-blockers, oral diuretics, and aldosterone receptor antagonists, that had not changed for over 4 weeks before recruitment; (4) voluntarily participation and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) any study medicines or devices used within 4 weeks before recruitment; (2) known or suspected allergy or intolerance to study drugs or any conventional treatments in this trial; (3) current acute decompensated heart failure or aggravated poor conditions, with lower limbs dysfunction, which may need intravenous medication; (4) percutaneous coronary intervention or coronary artery bypass grafting or implantation of a pacemaker in the past 3months; (5) uncontrolled hypertension with systolic blood pressure (SBP) = 180 mmHg or diastolic blood pressure (DBP) = 100 mmHg, or severe arrhythmia; (6) serum creatinine > 2.5 times ULN, or serum bilirubin or AST or ALT > 2 times ULN at first visit; (7) history of malignant tumor within 5 years; (8) female participants who are pregnant, breast-feeding or have a positive pregnancy test; (9) any other reasons that the main researchers consider inappropriate for participation in the clinical trial that may affect the efficacy and/or safety evaluation of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart function; | — |
Secondary
| Measure | Time frame |
|---|---|
| 6MWD;quality of life;TCMSS;1-year rehospitalization;1-year mortality;withdraw rate of digoxin;withdraw rate of diuretics; | — |
Countries
China
Contacts
Public ContactJiang Meixian
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed