Children undergoing day surgery
Conditions
Interventions
group of intranasal dexmedetomidine combined with oral mucosal esketamine:Children were administered a mixture of esketamine injection and monosodium syrup 0.5 mg/kg via the oral mucosa and dexmedetom
group of intranasal dexmedetomidine alone:Children were administered monosodium syrup 0.02 ml/kg via the oral mucosa and dexmedetomidine 2 µg/kg via nasal nebulization
Sponsors
Guangzhou Medical University Affiliated Women and Children's Medical Center
Eligibility
Sex/Gender
All
Age
2 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1.Children undergoing day surgery at the Guangzhou Medical University Affiliated Women and Children's Medical Center or Foshan Women and Children's Hospital; 2.Age 2-6 years old; 3.The American Society of Anesthesiologists (ASA) assessment level is level I-III;
Exclusion criteria
Exclusion criteria: 1. Obstructive sleep apnea syndrome, cardiopulmonary disease (e.g., uncorrected congenital heart disease, primary or secondary pulmonary hypertension, asthma, or structural lung disease); 2. neuromuscular disease; 3. history of psychiatric illness; 4. bradycardia; 5. hypotension; 6. ongoing treatment with digoxin, alpha-adrenergic or beta-adrenergic agonists or antagonists; 7. allergy to dexmedetomidine; 8. allergy to esketamine;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of children with UMSS greater than or equal to 2 at venipuncture; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sedation onset time;Serum levels of epinephrine, norepinephrine, cortisol and blood glucose ;Occurrence of adverse reactions;numerical rating scale;Quality of sleep; | — |
Countries
China
Contacts
Public ContactBilian Li
Guangzhou Women and Children's Medical Center
Outcome results
None listed