knee osteoarthritis
Conditions
Interventions
Test group:The modified Buyang-Huanwu decoction and conventional anticoagulation regimen were used.
Sponsors
Wangjing Hospital of China Academy of Chinese Medicine Sciences
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Subjects had to meet all of the following inclusion criteria: (1) 50 years old = enrollment age =80 years old; (2) patients who met the diagnosis of KOA and the indications for TKA; (3) no previous history of thrombosis related diseases within half a year; (4) primary unilateral TKA without contraindication; (5) patients without thrombosis by color Doppler ultrasound before operation; (6) able to cooperate with the follow-up and have good compliance; (7) voluntarily participated in the trial and signed the informed consent form in person.
Exclusion criteria
Exclusion criteria: Subjects could not meet any of the following exclusion criteria: (1) those who did not meet the inclusion criteria; (2) patients with serious underlying medical diseases, including cardiopulmonary dysfunction, liver and kidney dysfunction or bone marrow hematopoietic dysfunction; (3) patients with abnormal coagulation function; (4) patients with allergic constitution or allergic to the drugs involved in this trial; (5) patients with previous history of gastrointestinal bleeding and bleeding tendency; (6) patients with severe mental illness; (7) those who participated in other investigational drug or device clinical trials within the past 3 months; (8) other situations considered by the investigators to be inappropriate for this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The lower limbs were examined by color Doppler ultrasound;Anemia indicators (Hb, Hct, MCV, MCH and MCHC);Coagulation indexes (D-dimer, APTT and PT); | — |
Secondary
| Measure | Time frame |
|---|---|
| Hidden blood loss;VAS score;HSS score; | — |
Countries
China
Contacts
Public ContactHongmei Zhang
Wangjing Hospital of China Academy of Chinese Medicine Sciences
Outcome results
None listed