interstitial cystitis
Conditions
Interventions
The experimental group:10 mL PRP (extracted from 50 mL of patients own whole blood) is injected into the bladder submucosa, and this process is repeated every 1 month for a total of 4 treatments
Sponsors
Gongli Hospital, Shanghai
Eligibility
Sex/Gender
Female
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: ?Refer to ‘the IC diagnostic criteria developed by the Guidelines for the Diagnosis and Treatment of Andrology Diseases in Urology in China’;? Age 18~85 years old (inclusive), female;? In the awake state, the bladder capacity is > 150 mL (there is no urgency to urinate when the bladder is filled with 150ml of liquid);? The previous drug treatment or physical therapy effect was not good, and the drug has been stopped for 2 weeks;? The 24-hour average pain score was greater than 4 points and less than 8 points.? Able to comply with study and follow-up procedures;? Voluntarily participate in this clinical trial and sign the informed consent form of the subject;
Exclusion criteria
Exclusion criteria: ? Other patients with chemical cystitis or tuberculous cystitis; ? People with urinary tract infection; ? Bladder tumors; ? In the awake state, the bladder capacity < 150 mL;? Pregnant women;? Allergic constitution,G6PD deficiency(favism)and hyperthyroidism are contraindications to ozone therapy; ? Patients treated with intravenous copper or iron are contraindicated to ozone therapy; ? Those with major diseases of the heart, liver and other systems are excluded;? Exclusion of those with poor compliance;? Those who have participated in other clinical trials within 1 month before the start of this trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ICSI(Interstitial Cystitis Symptom Index Score);SAS(Self-Rating Anxiety Scale);Average urination volume per session;Maximum urination volume; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICPI(Interstitial Cystitis Problem Index Score);GRA(Interstitial Cystitis Problem Index Score);VAS(Visual Analogue Scale for Pain);PUF(Pelvic Pain and Urgency/Frequency Symptom Scale);Average number of urinations per 24 hours; | — |
Countries
China
Contacts
Public ContactJianwei Lyv
Gongli Hospital, Shanghai
Outcome results
None listed