IgA nephropathy
Conditions
Sponsors
The Second Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Willing to sign an informed consent form for medication and follow-up; 2. Patients diagnosed with IgA nephropathy through renal biopsy; 3. Ages older than 18 years; 4. eGFR > 15 ml/min per 1.73m^2 (using the CKD-EPI formula); 5. Urinary protein = 0.75 g/24h; 6. Patients who, in the clinician's judgment, require initiation of immunosuppressive therapy after receiving adequate supportive care.
Exclusion criteria
Exclusion criteria: 1. IgA vasculitis, and IgA nephropathy with clear secondary causes; 2. Patients with IgA nephropathy requiring high-dose hormone shock therapy in clinical judgment, including, but not limited to, patients with other types of glomerular disease such as crescentic nephritis (pathologic diagnosis present in >50% of cases); 3. Patients in whom other types of glomerular disease cannot be definitively ruled out, such as membranous nephropathy with IgA deposits or minimal change disease with IgA deposits, etc; 4. Patients with severe underlying diseases; 5. Received other biologic agents within 24 weeks prior to enrollment; 6. Subjects deemed unsuitable by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in proteinuria; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in glomerular filtration rate (GFR);Changes in urinary albumin-to-creatinine ratio (ACR) ; | — |
Countries
China
Contacts
Public ContactBingjuan Yan
The Second Hospital of Shanxi Medical University
Outcome results
None listed