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Development and validation of portal hypertension assessment model based on 4D Flow MRI

Development and validation of portal hypertension assessment model based on 4D Flow MRI

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400083985
Enrollment
Unknown
Registered
2024-05-08
Start date
2024-05-10
Completion date
Unknown
Last updated
2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Portal hypertension

Interventions

Gold Standard:hepatic venous pressure gradient/portal venous pressure gradient (HVPG/PPG)
Index test:analysis of four-dimensional blood flow magnetic resonance images

Sponsors

The Fifth Medical Center of PLA General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: ?Patients scheduled for HVPG or PPG measurement; ?Age =18 years

Exclusion criteria

Exclusion criteria: ?Patients who have previously undergone one of the following procedures: TIPS, splenectomy, liver transplantation, or partial hepatectomy; ?Patients with one of the following conditions: portal vein cavernous transformation, congenital abdominal vascular malformation, Budd-Chiari syndrome; ?Enhanced CT/ MRI showed the patients with obvious hepatic arterio-portal fistula and hepatic arterio-hepatic venous fistula. ?MR Scanning contraindications or poor patient cooperation

Design outcomes

Primary

MeasureTime frame
net flow;flow per second;average flow velocity;maximum flow velocity;regurgitant fraction;wall shear stress;Accuracy ;

Secondary

MeasureTime frame
Sensitivity ;Specificity ;Positive predicative value;Negative predictive value;

Countries

CHINA

Contacts

Public ContactDong Jinghui

The Fifth Medical Center of PLA General Hospital

zhangmengby@gmail.com+86 138 1133 3975

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026