Cognitive impairment
Conditions
Interventions
Group A:Remote ischemic preconditioning therapy instrument
Group B:Remote ischemic preconditioning control instrument
Sponsors
Weihai Municipal Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.The diagnosis of type 2 diabetes meets the American Diabetes Association clinical diagnostic criteria 2.Age 60-80 years old 3.Mild cognitive impairment meets the revised Mayo Clinic diagnostic criteria:1)Subjective cognitive impairment;2)Objective impairment in one or more cognitive areas;3)The ability to carry out complex daily living is slightly impaired, but the ability to maintain independent daily living is maintained;4)Not enough to diagnose dementia.(MMSE: Illiterate =17 points, primary education =20 points, secondary education =22 points, university education =23 points) 4.MoCA score < 26, clinical dementia Scale score 0.5, Hamilton17 = 12 5.Agree to participate in the study and sign the informed consent. The patient has clear consciousness and can cooperate with himself or with the help of his family to complete the examination operation, questionnaire survey, history collection, etc.
Exclusion criteria
Exclusion criteria: 1. Patients with intracranial hemorrhage (parenchymal hemorrhage, subarachnoid hemorrhage, subdural/epidural blood) and history of severe trauma within 3 months before enrollment 2.Expected major surgery within 30 days prior to enrollment or within 6 months after enrollment (including femoral, heart, aortic, or carotid surgery) 3.Have uncontrolled severe hypertension (systolic blood pressure > 180mmHg or diastolic blood pressure > 110mmHg after medication) 4.History of serious heart disease such as rheumatic mitral or aortic stenosis, artificial heart valves, atrial fibrillation, atrial flutter, sick sinus syndrome, left atrial myxoma, patent foramina ovale, left ventricular mural thrombosis or valve neoplasms, congestive heart failure, bacterial endocarditis, or any other cardiovascular disease that is not eligible for inclusion 5.History of intracranial tumors or brain aneurysms, arteriovenous malformations 6.People with severe blood system diseases or severe coagulation abnormalities 7.People with hyperthyroidism or hypothyroidism 8.Laboratory test indicators failed: glutamic oxalacetic transaminase or glutamic pyruvic transaminase was 3 times higher than the upper limit of normal, creatinine clearance 265umol/l (> 3.0mg/dl), platelet < 100×109/L 9.Patients with contraindication of remote ischemic preconditioning, such as severe soft tissue injury, fracture or vascular injury in the upper limb, and peripheral vascular disease in the distal upper limb
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxious ;Depression;Sleep; | — |
Countries
China
Contacts
Public ContactZhang Jin biao
Weihai Municipal Hospital
Outcome results
None listed