gastric cancer with liver metastases
Conditions
Interventions
Cohort A/ Cohort B/ Cohort C:None
Sponsors
PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. patients aged =18 years with GCLM with or without other distant metastasis. 2. gastric primary lesions confirmed by pathology and liver metastases confirmed by pathology or imaging (before, during, or after initial treatment). 3. GCLM diagnosed between July 1, 2024 and December 31, 2026. 4. expected survival time of = 12 weeks. 5. a score of 0-2 according to the Eastern Cooperative Oncology Group Physical Status Score (ECOG PS score). 6. signed informed consent. 7. good compliance and ability to complete regular follow-up.
Exclusion criteria
Exclusion criteria: 1. heterochronous liver metastases. 2. multi-center clinics with serious missing case information. 3. diagnosed or suspected autoimmune disease, or in active stage. 4. known history of primary immunodeficiency. 5. known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation. 6. pregnant or breastfeeding female patients. 7. uncontrolled co-morbidities, including but not limited to: 1)HIV-infected (HIV-positive) patients, 2)severe infections that are active or poorly controlled clinically, 3)evidence of the presence of severe or uncontrolled systemic disease (e.g., severe psychiatric, neurologic disease, epilepsy or dementia, unstable or uncompensated respiratory, cardiovascular, hepatic or renal disease, uncontrolled hypertension [Refers to hypertension that is still greater than or equal to CTCAE level 2 after drug treatment]. 4) Abnormal coagulation (INR > 1.5 x ULN, APTT > 1.5 x ULN) in those with active bleeding or new thrombotic disease who are taking therapeutic doses of anticoagulant medication or who have a bleeding tendency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 2-year OS; | — |
Secondary
| Measure | Time frame |
|---|---|
| OS;R0 resection rate;DFS;convertion successful rate;EFS; | — |
Countries
China
Contacts
Public ContactCHEN Lin
Department of General Surgery, First Medical Center, General Hospital of the PLA
Outcome results
None listed