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A Randomized Controlled Study on the Impact of Plasma NT-proBNP During the Perioperative Period in Patients with Severe Benign Prostatic Hyperplasia Undergoing Madigan and Trans-urinary Enucleation of Prostate (TUEP)

A Randomized Controlled Study on the Impact of Plasma NT-proBNP During the Perioperative Period in Patients with Severe Benign Prostatic Hyperplasia Undergoing Madigan and Trans-urinary Enucleation of Prostate (TUEP)

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400083952
Enrollment
Unknown
Registered
2024-05-08
Start date
2024-05-10
Completion date
Unknown
Last updated
2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

benigh prostate hyperplasia

Interventions

Madigan Group:Performing a Madigan procedure to preserve the urethra while removing the enlarged prostate
Transurethral Enucleation of the Prostate Group (TUEP, Group T):Transurethral enucleation of the prostate (TUEP) for the removal of the enlarged prostate gland

Sponsors

The Third Affiliated Hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
65 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Patients over the age of 65 with severe benign prostatic hyperplasia (BPH), with a prostate volume greater than 80ml. 2. Meeting one of the following conditions: - Ineffective medical treatment. - More than two episodes of urinary retention. - Concurrent hernia. - Recurrent urinary and genital system infections. - Recurrent hematuria.

Exclusion criteria

Exclusion criteria: 1. Sepsis. 2. Preoperative use of inotropic drugs. 3. Severe history of heart failure (defined as an ejection fraction <30%). 4. Urethral stricture. 5. Renal insufficiency. 6. Weak bladder contraction. 7. Neurogenic bladder. 8. Other contraindications for surgery.

Design outcomes

Primary

MeasureTime frame
NT-proBNP;—

Secondary

MeasureTime frame
The incidence of myocardial injury after noncardiacsurgery;—

Countries

China

Contacts

Public ContactWang Yu

The Third Affiliated Hospital of Sun Yat-sen University

wangyu79@mail.sysu.edu.cn+86 139 2957 1713

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026