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Exploring the effect of positive antinuclear antibodies on pregnancy and their role in the occurrence of miscarriage

Exploring the effect of positive antinuclear antibodies on pregnancy and their role in the occurrence of miscarriage

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400083946
Enrollment
Unknown
Registered
2024-05-08
Start date
2024-05-08
Completion date
Unknown
Last updated
2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

abortion

Interventions

case series:none

Sponsors

Hangzhou First People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Age between 18 and 45 years old;2.Intrauterine pregnancy confirmed by medical institutions and gestational age =13+6 weeks;3. desire to continue the pregnancy; 4.To maintain the condition of regular prenatal examination;5.Women eligible to know pregnancy outcome or postpartum follow-up.

Exclusion criteria

Exclusion criteria: [1] Age 45 years old; [2] A history of recurrent miscarriage, defined as three or more consecutive abortions; [3] Pathogenic chromosomal abnormalities of the patient or his husband; [4] Massive vaginal bleeding or severe abdominal pain, abortion is inevitable according to medical judgment; [5] Transvaginal ultrasound examination showed that there was no embryo when the germ was =7mm without primitive heart tube pulse, or the average gestational sac diameter was =25mm. [6] patients with known autoimmune diseases who are receiving treatment; [7] Pregnant women with severe medical or surgical conditions (one of the following) : 1. Severe hypertension (systolic blood pressure > 180 MMHG or diastolic blood pressure > 110 MMHG); 2. Severe diabetes (fasting plasma glucose level > 11.1mmol/L); 3. History of malignant tumor; 4. Patients with cardiovascular and cerebrovascular diseases (NYHA class III-IV); [8] Acute infection with/without body temperature =38.5?; [9] Had participated in another clinical trial of research drugs within 3 months before enrolling in this study (the first interview); [10] Those who met the inclusion criteria, did not follow the doctor's advice, could not judge the efficacy, or had insufficient data to evaluate the efficacy.

Design outcomes

Primary

MeasureTime frame
Antinuclear antibodies;Pregnancy Outcomes;

Secondary

MeasureTime frame
Blood pressure;Hemoglobin;C-reactive protein;Fasting blood glucose;Fetal nuchal translucency;

Countries

china

Contacts

Public Contacthong cai

Hangzhou First People's Hospital, Zhejiang Province

jikang_ch@126.com+86 135 8874 8831

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026