Patients who plan to undergo Elective surgery under general anesthesia and mechanical ventilation
Conditions
Interventions
target-controlled infusion of Propofol under Marsh model :None
target-controlled infusion of Propofol under Schnider model :None
Propofol under closed-loop controlled infusion:None
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria were as follows: patients undergoing elective surgeries under general anesthesia with an expected operation duration of =3 hours, encompassing but not limited to the following types: patients with breast lesions undergoing breast lesion resection, patients with thyroid tumors undergoing thyroid tumor excision, patients with lower limb surgeries such as high ligation and stripping for varicose veins, or patients with gallstones undergoing laparoscopic cholecystectomy, comprising a total of 54 cases; 18 = Age<65 years old; a gender ratio of 1:1 (male/female); body mass index (BMI) between 18.5 kg/m² and 30 kg/m²; and an American Society of Anesthesiologists (ASA) physical status classification of I or II.
Exclusion criteria
Exclusion criteria: Exclusion criteria: Patients with preoperative organic baseline diseases or dysfunction in major organs such as heart, liver, lung, kidney, or blood; those with a history of surgery or functional impairment; patients with a history of long-term use of psychotropic drugs, alcohol abuse, or allergies to soy, milk, or experimental drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| concentration of exhaled propofol ; | — |
Secondary
| Measure | Time frame |
|---|---|
| SBP, DBP, MAP;Bispectral index;heart rate; | — |
Countries
China
Contacts
Public ContactZhang Wensheng
West China Hospital, Sichuan University
Outcome results
None listed