The application of ciprofol for sedation in foot and ankle surgery with lower limb tourniquet

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400083924

Enrollment

Unknown

Registered

2024-05-07

Start date

2024-05-07

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Propofol group:propofol

Ciprofol group:ciprofol

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: ? Patients undergoing foot and ankle surgery (including internal fixation of foot and ankle fracture,orthomorphia of hallux valgus, debridement and suture of foot and ankle skin, etc.) and requiring the use of lower limb tourniquet during the operation; ? Patients aged 18-60 years old; ? American Association of Anesthesiologists (ASA) grade I-II; ? Sign informed consent;

Exclusion criteria

Exclusion criteria: ? have serious heart, lung, liver, renal dysfunction and immune system diseases; ? All kinds of antioxidant and anti-inflammatory drugs were not stopped one week before surgery; ? contraindications of peripheral nerve block; ? Patients allergic to ciprofol, propofol and other narcotic drugs; ? Tourniquet use time < 40 min; ? Patients with intraoperative changes in anesthesia mode; ?BMI = 30 kg/m2 ;

Design outcomes

Primary

Measure	Time frame
blood pressure;heart rate;BIS;	—

Secondary

Measure	Time frame
malondialdehyde;Superoxide dismutase;Tumor necrosis factor;	—

Countries

China

Contacts

Public ContactZhu Bingqing

Southern District of the First Affiliated Hospital of University of science and technology of China

zhubqmedical@163.com+86 136 9677 2833

Outcome results