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The effect of bupivacaine and liposome bupivacaine in the parasacral ischial plane on postoperative analgesia for total knee arthroplasty: A single-center, double-blind, randomized controlled study

The effect of bupivacaine and liposome bupivacaine in the parasacral ischial plane on postoperative analgesia for total knee arthroplasty: A single-center, double-blind, randomized controlled study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400083921
Enrollment
Unknown
Registered
2024-05-07
Start date
2024-05-07
Completion date
Unknown
Last updated
2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee joint disease

Interventions

group I:the parasacral ischial plane was injected with liposomal bupivacaine
group ?:the parasacral ischial plane was injected with bupivacaine

Sponsors

Fujian Provincial Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Requires unilateral total knee arthroplasty. 2.Age 18-80 years. 3.ASA I-II grade. 4.BMI 18-30 kg/m^2. 5.Voluntary and signed informed consent form. 6.Ability to walk independently for at least 20 meters. 7.Normal sensory function in the distribution area of the sciatic nerve.

Exclusion criteria

Exclusion criteria: 1.Preoperative opioid therapy. 2.Allergic to the study drug. 3.Unable to use or understand patient-controlled analgesia (PCA) device. 4.Infection at the site of nerve block puncture. 5.Ultrasound could not identify the anatomical structure or identify the body surface location. 6.Nerve disorders. 7.Coagulation dysfunction. 8.Those who refuse to sign informed consent.

Design outcomes

Primary

MeasureTime frame
Pain score;Blocking onset time;Duration of sensory block;Duration of motor block;Knee joint range of motion;

Secondary

MeasureTime frame
Consumption of opioid medications;Rescue analgesia time and frequency;Satisfaction with pain management;Adverse reactions;Duration of hospitalization;

Countries

China

Contacts

Public ContactZheng Ting

Department of Anesthesiology, Fujian Provincial Hospital

zhengting1223@163.com+86 156 5911 5373

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026