The effect of bupivacaine liposomes on postoperative pain in patients undergoing shoulder surgery under general anesthesia: a multicenter, randomized, double-blind, controlled clinical trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400083893

Enrollment

Unknown

Registered

2024-05-07

Start date

2024-06-01

Completion date

Unknown

Last updated

2024-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative pain

Interventions

Group B:Using 1.33% bupivacaine liposomes 266mg for preemptive analgesia

Group R:Using 0.5% ropivacaine 100mg for preemptive analgesia

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) Patients participate this research project voluntarily; (2) Patients have clear mental state, can communicate and cooperate with anesthesiologist; (3) Patients undertake elective shoulder surgery under general anesthesia; (4) Patients are classified as ASA physical status I to II; (5) Patient's age is = 18 years old, = 65 years old; (6) Patient's BMI is = 18.5 and = 28.

Exclusion criteria

Exclusion criteria: (1) Patients refuse to participate in this research project; (2) Patients have psychiatric disorders, unable to communicate or cooperate with anesthesiologist; (3) Patients have a history of upper limb neuromuscular injury; (4) Patients have a history of peripheral neuropathy; (5) Patients have a history of allergic reactions to local anesthetics; (6) Patient's age is 65 years old; (7) Patient's BMI is 28; (8) Patients have severe liver or kidney dysfunction; (9) Patients have severe circulatory or respiratory system diseases; (10) Patients have malignant tumors; (11) Patients have diabetes; (12) Patients have severe coagulation dysfunction; (13) Patients have histories of long term alcoholism, use of sedatives, hypnotics, anesthetic analgesics, or other psychiatric drugs; (14) Patients have received hormone therapy within the past six months; (15) Pregnant and lactating women; (16) Patients unable to provide accurate and complete medical history information.

Design outcomes

Primary

Measure	Time frame
Time of onset ;Time of duration;	—

Secondary

Measure	Time frame
Pain score;Perioperative adverse events;	—

Countries

China

Contacts

Public ContactChen Yongquan

Department of Anesthesiology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)

chenyq263@163.com+86 139 5619 6920

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026