Major depressive disorder
Conditions
Interventions
Acitve transcranial alternating current stimulation (tACS) group:Active transcranial alternating current stimulation.
Sham transcranial alternating current stimulation (tACS) group:Sham transcranial alternating current stimulation.
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
13 Years to 17 Years
Inclusion criteria
Inclusion criteria: ? Being diagnosed with major depressive disorder based on the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) criteria, ? Being experiencing their first depressive episode, but no history of receiving any treatment with antipsychotic medications, ? HAMD-17 total score =17, ? Age between 13 and 17, with at least 6 years of education, and ? Han ethnicity, right-handed.
Exclusion criteria
Exclusion criteria: ?History of severe physical or organic brain diseases, as well as history of cranial trauma, ? previous or current exposure to electroconvulsive therapy (ECT), modified electroconvulsive therapy (MECT), TMS, tDCS, tACS or other neurostimulation treatments, ? History of medication, alcohol, or other substance abuse, ? Presence of metallic objects in the body, such as cardiac pacemakers, ? A score of >1 on the Beck Suicidal Ideation Inventory (SSI) before or during treatment for item 4 (How much do you actively wish to attempt suicide) or item 5 (How much do you wish for an external force to end your life, i.e., how much do you have "passive suicidal ideation").
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response rate;Remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects;Neurocognitive function;Suicide ideation; | — |
Countries
China
Contacts
Public ContactZheng Wei
The Affiliated Brain Hospital of Guangzhou Medical University
Outcome results
None listed