major depressive disorder
Conditions
Interventions
Aerobic exercise group:The exercise prescription was formulated according to the ACSM Exercise Testing and Exercise Prescription Guidelines (10th Edition) prepared by the American College of Sports Me
Sponsors
Peking University Sixth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. aged 18-60 years (including 18 and 60 years), gender-neutral, Han Chinese; 2. meet the Diagnostic and Statistical Manual of Mental Disorders-fifth edition (DSM-5) diagnostic criteria for depressive disorders through the Mini-International Neuropsychiatric Interview (MINI). 3. outpatient or inpatient; Hamilton Depression Scale 17 (HAMD17) = 14; negative Mood Disorder Questionnaire (MDQ) screen to exclude patients with bipolar disorder; and Clinical Global Impressions-Severity (CGI-S) score = 4; 4. maintenance antidepressant monotherapy (SSRI class) at a dose of: fluoxetine equivalents 20-40 mg/d. Laura 0.5 mg/dose and Snus 5-10 mg/n may be combined in insomnia and anxiety episodes; 5. written informed consent was obtained from the patient.
Exclusion criteria
Exclusion criteria: 1. persons who meet the diagnosis of other mental disorders, including schizophrenia, bipolar disorder, alcohol or drug abuse/dependence, etc; 2. persons who are intellectual disabled and otherwise unable to cooperate, or who are incapacitated or have incomplete civil capacity during the period of onset of the disease 3. those suffering from neurological disorders and organic brain diseases (e.g. stroke, brain hemorrhage, brain tumor, Parkinson's disease, epilepsy, etc.) and history of severe traumatic brain injury 4. suffering from diseases with high risk of exercise such as high blood pressure and heart disease 5. those who are undergoing systematic psychological treatment; 6. cardiorespiratory fitness 3-minute step test with recovery heart rate >131 for males and >140 for females; 7. persons with physical limitations that prevent them from participating in physical activity; 8. who have a Physical Activity Readiness Questionnaire (PAR-Q) score of =2; 9. those who are pregnant or have contraindications to magnetic resonance imaging (MRI) examination 10. those who are severely suicidal or at risk of injury;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD Hamilton Depression Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montgomery-?sberg Depression Rating Scale (MADRS);Thinc-Integrated Tool (THINC-it) ; | — |
Countries
China
Contacts
Public ContactWeihua Yue
Peking University Sixth Hospital
Outcome results
None listed