painless gastroscopy
Conditions
Interventions
Normal group:Each group of patients was tested separately using the Dixon sequential method, with the initial dose of cyclobutrazol set at 0.4 mg/kg and a dose gradient of 0.04 mg/kg. The presence of
conversely, the dose of the next patient was decreased by 0.04 mg/kg. If the modified alertness/sedation score was still >1 after 3 min of injection of cyclobutrazol, it was directly judged as ineffec
drinking group:Each group of patients was tested separately using the Dixon sequential method, with the initial dose of cyclobutrazol set at 0.4 mg/kg and a dose gradient of 0.04 mg/kg. The presence o
Sponsors
Baoding NO.1 Central Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Male patients who to undergo elective painless gastroscopy; 2. Age< 65 years old; 3BMI <28kg\/m2; 4. ASAI. or Class II; 5. Mouth opening=2.5cm;6. Normal range of motion of head and neck; 7. Mallampati Class I or II; 8. No history of alcohol consumption within 24 hours; 9. The patient has fully understood the nature of the study, voluntarily participated in this trial and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Neuromuscular junction disease; 2. History of allergy to the test drug; 3. History of neurological diseases; 4. High risk of inhalation; 5. Expected airway difficulties; 6. Use sedatives; 7. Alcoholics, daily alcohol consumption greater than 100g and alcohol withdrawal symptoms (tremor, agitation, disorientation dysfunction) or acute alcohol poisoning; 8. Severe smokers; 9. For any reason, the investigators believe that there are any circumstances that are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| median effective dose; | — |
Secondary
| Measure | Time frame |
|---|---|
| SpO2, HR and MAP were recorded before anesthesia (T0), 1min after injection (T1) and gastroscopy (T2);Adverse effects such as bradycardia, hypotension, hypoxia, choking, body movement, and swallowing during the induction period; | — |
Countries
China
Contacts
Public ContactChunguang Wang
Baoding NO.1 Central Hospital
Outcome results
None listed