Hypoxemia
Conditions
Interventions
control group:Intravenous injection of propofol and ketamine
treatment group:Intravenous injection of Remazolam Besylate and Esketamine
Sponsors
The Second People's Hospital of Shenzhen
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Patients who plan to undergo painless digestive endoscopy examination and diagnosis and treatment; (2) Patients aged = 18 years old; (3) Body mass index (BMI) = 25 kg/m ²; (4) The American Society of Anesthesiologists (ASA) is classified as Grade II-III. (5) The subjects voluntarily participate and sign an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients who refuse to participate in the trial; (2) Individuals with a history of severe heart, brain, lung, liver, kidney, and metabolic diseases; (3) Within 2 weeks, there is a history of acute respiratory inflammation that has not been cured; (4) Preoperative systolic blood pressure in hypertensive patients = 180mmHg and/or diastolic blood pressure = 110mmHg, or hypotension patients<90/60mmHg; (5) Individuals with neuromuscular system diseases or mental illnesses; (6) Suspected misuse of anesthetic analgesics or sedatives; (7) Individuals who are allergic to drugs such as propofol, ketamine, and remrazolam besylate; (8) Those who are uncooperative and unable to communicate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of hypoxemia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Absolute value of pulse oxygen saturation;Mean arterial pressure;heart rate;respiratory rate;BIS value;inspection time;Wake-up time;Time of leaving the recovery room;MOAA/S scores;CAM scores;Dosage of Remazolam Benzenesulfonate;Dosage of propofol;Adverse reaction occurrence; | — |
Countries
China
Contacts
Public ContactYang Han
The Second People's Hospital of Shenzhen
Outcome results
None listed