Weaning-induced Pulmonary Oedema
Conditions
Interventions
Group 1:Pressure-Support Ventilation
Group 2:After disconnecting the tracheal tube from the ventilator, connect the T-shaped connector to the end of the tracheal tube and provide an additional oxygen supply of = 6L/min (FiO2 = 40%) throu
Sponsors
The First Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. age = 18 years; 2. mechanical ventilation duration = 24h; 3. patients with high-risk factors for developing WIPO: preexisting cardiovascular disease[including: hypertension, atrial fibrillation, structural heart disease (defined as dilated cardiomyopathy, hypertrophic cardiomyopathy, and significant valvular disease), coronary artery disease, sepsis-phase-associated heart disease, and an LVEF of <45%], chronic obstructive pulmonary disease, or obesity; 4. meeting the criteria for daily withdrawal screening; 5. the study complied with the Declaration of Helsinki and Chinese clinical trial research regulations, and patients or their families were informed and consented to participate in the trial.
Exclusion criteria
Exclusion criteria: 1. patients who have received initial SBT at any time; 2. patients with tracheotomy; 3. patients who refuse to be reintubated after extubation; 4. patients on prolonged mechanical ventilation: consecutive mechanical ventilation for 21days, more than 6 hours per day; 5. the attending physician decides on the withdrawal protocol (e.g. special withdrawal modalities are preferred based on underlying physiology).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of weaning-induced pulmonary oedema; | — |
Secondary
| Measure | Time frame |
|---|---|
| Extubation success rate;ICU stay;Hospital stay;Hospital mortality;28-day mortality; | — |
Countries
China
Contacts
Public ContactXiaoyun Li
The First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed