Postoperative cognitive dysfunction
Conditions
Interventions
Control group:None
Case group:None
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 18-65 years old; Patients undergoing cardiac surgery under cardiopulmonary bypass perfusion; Voluntarily signed informed consent;
Exclusion criteria
Exclusion criteria: History of dementia; Inability to complete cognitive tests due to speech, vision, or hearing impairment; Preoperative diabetes mellitus, chronic kidney disease, ulcerative colitis, Crohn's disease, diarrhea, or other infectious diseases; Patients who had undergone gastrointestinal surgery or chemoradiotherapy; Taking drugs or foods that can affect the flora within 3-6 months before surgery; Female menstrual period; After operation, more than three generations of cephalosporins or antibiotics were used for more than 3 days. The length of ICU stay was greater than 3 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma levels of I-FABP, D-Lactate, and ZO-1 were determined; | — |
Secondary
| Measure | Time frame |
|---|---|
| 16SrRNA sequencing of fecal microbiota;Postoperative Delirium; | — |
Countries
China
Contacts
Public ContactLu Xiaoxing
Xuzhou Central Hospital
Outcome results
None listed