esophageal cancer
Conditions
Interventions
Group 1:Immunotherapy was added within 60 days after concurrent chemo-radiotherapy.
Group 2:Immunotherapy was added without 60 days after concurrent chemo-radiotherapy.
Sponsors
Weihai Municipal Hospital,Cheeloo College of Medicine,Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age =18 years old, ECOG score 0 or 1-2; (2) No congestive heart failure, unstable angina pectoris, or unstable arrhythmia occurred in the past 6 months; Life expectancy assessment > 3 months; (3) no previous history of immune disease; (4) Esophageal cancer without perforation signs; (5) Radiotherapy dose of at least 4500cGy; (6) Be able to adhere to the protocol for the study period; (7) The patient should undergo chest CT scan and esophageal barium meal examination; Adequate bone marrow function; Adequate liver function; Full renal function.
Exclusion criteria
Exclusion criteria: (1) Esophageal perforation; (2) Presence of esophageal stent, potential gastrointestinal bleeding or massive gastrointestinal bleeding; (3) Allergic disease, history of severe drug allergy, known to be allergic to immune drugs; (4) The presence of any active autoimmune disease or a history of autoimmune disease; (5) Concurrent severe infection (such as intravenous use of antibiotics, antifungal or antiviral drugs, etc. (6) Congenital or acquired immune deficiency or active hepatitis; (7) Mental illness that interferes with study compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total reaction rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| safety;progression free survival;overall survival;Pneumonia incidence rate; | — |
Countries
China
Contacts
Public ContactWang Shuwei
Weihai Municipal Hospital,Cheeloo College of Medicine,Shandong University
Outcome results
None listed