gastrointestinal endoscope
Conditions
Interventions
GroupA: remimazolam group 0.25mg/kg:sufentanil 0.1ug/kg iv, 1min later, remimazolam 0.25mg/kg iv
GroupB: propofol group 1.5mg/kg:sufentanil 0.1ug/kg iv, 1min later, propofol 1.5mg/kg iv
GroupC: remimazolam: propofol 1:7 group:sufentanil 0.1ug/kg iv, 1min later, remimazolam 0.1mg/kg iv, propofol 1.5mg/kg iv
Sponsors
Shenzhen University General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) ASA I-II, age: 18-65 years old, gender unlimited 2) BMI less than 28, blood pressure not less than 90/50mmHg, heart rate 50-100 bpm 3) No complications of cardiac cerebrovascular, liver, kidney and lung diseases 4) No sleep apnea syndrome or underlying breathing difficulties 5) No antipsychotic and insomnia drugs have been taken in the past month or for a long time 6) Patients who signed informed consent
Exclusion criteria
Exclusion criteria: 1) Patients with cardiovascular and cerebrovascular diseases, lung, liver and kidney diseases 2) Patients with sleep apnea syndrome or potential breathing difficulties, Mallampati>3 and above 3) History of mental disorders 4) People who are allergic to benzodiazepines, propofol adjuvants such as soy, broad beans, glycerin and lecithin 5) Preparation for pregnancy, pregnancy or lactation period 6) Patients who have taken antipsychotics and painkilling drugs within one month or for a long time 7) Serious psychological disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphine-Benzedrine Group (MBG) score;modified Brice questionnaire; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Scale;hospital anxiety and depression scale;Dream emotional experience;Number Tail Making Test (NTMT);Number Cancellation Tests (NCT);Incidence of respiratory depression;Incidence of cough;Incidence of hypotension;Incidence of bradycardia; | — |
Countries
China
Contacts
Public ContactYanyan Sun
Shenzhen University General Hospital
Outcome results
None listed