Lung cancer / Postoperative delirium
Conditions
Interventions
Group T:Anesthesia induction: Esketamine (0.25mg/kg) Anesthesia maintenance: Esketamine 0.1mg/kg/h continuous infusion for 30min.
Sponsors
Ningbo Medical Center Li Huili Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Elderly patients with fragile brain function include: history of chronic stroke, transient ischemic attack, cerebral infarction lesions with clear medical images (including lacunar infarction), moderate to severe craniocerebral vascular stenosis, Alzheimer's disease, Parkinson's disease, etc. 2. age 65-80 years old 3. ASA classification: II ~ III 4 .expected operation time 2-5 hours
Exclusion criteria
Exclusion criteria: ? long-term use of psychotropic drugs ? alcoholism, drug dependence ? heart, lung and major organ dysfunction ? second surgery ?MMSE score <23
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium;Serum interleukin-6 (IL-6) and calc-binding protein ß(S100ß); | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative dosage of propofol, sufentanil, remifentanil, operation time, anesthesia time, postoperative extubation time, recovery room residence time, and total postoperative hospital stay.;HR, MAP, SPO2 of patients at different time points; | — |
Countries
China
Contacts
Public ContactHonglin Fu
Ningbo Medical Center Li Huili Hospital
Outcome results
None listed