Septic shock
Conditions
Interventions
Active net ultrafiltration strategy group:After enrollment, the initial net ultrafiltration rate is set at 0.5 ml/kg.h. After assessing the patients tolerance, it is adjusted upward by 0.5 ml/kg.h eve
Restricted net ultrafiltration strategy group:After enrollment, the initial net ultrafiltration rate is also set at 0.5 ml/kg.h. After assessing the patients tolerance, it is adjusted upward by 0.5 ml
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. ICU hospitalized patients diagnosed with septic shock Septic shock diagnosis aligning with the 2016 third edition of the international consensus definitions for sepsis and septic shock (Sepsis 3.0). 2. Meeting the diagnostic criteria for Acute Kidney Injury (AKI) (KDIGO Stage 3) Diagnosis of acute kidney injury conforms to the standards set forth by the 2012 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. 3. Age: 18 years or older 4. Clinical judgment by physicians indicating the need for continuous renal replacement therapy for fluid management 5. Regardless of patient consciousness or cooperation, willingness of the patient or guardian to participate in the study and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Respiratory failure due to pulmonary edema and volume overload. 2. Clinical judgment by the attending physician indicating inadequate conditions for fluid removal. 3. Patients with severe obesity (body weight greater than 100 kg). 4. Patients with a history of renal failure who regularly undergo hemodialysis. 5. Patients who received continuous renal replacement therapy with fluid removal in other treatment units before ICU admission. 6. Patients receiving ECMO therapy. 7. Patients in critical condition, expected to die within 48 hours, or with a SOFA score = 15, or APACHE II score = 35, or patients refusing active treatment. 8. Expected duration of CRRT application is less than 24 hours. 9. Pregnant or lactating women. 10. Participants who have participated in other interventional clinical trials within the past 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative fluid balance; | — |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality;non-renal SOFA score; | — |
Countries
China
Contacts
Public ContactJin Lin
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed