Postoperative extubation/awakening time
Conditions
Interventions
Physiological saline group:Normal saline
Low concentration ketamine group (0.1mg/kg):Low concentration ketamine
Medium concentration ketamine group (0.3mg/kg):Medium concentration ketamine
High concentration ketamine group (0.5mg/kg):High concentration ketamine
Sponsors
Guangzhou Women and Children’s Medical Center
Eligibility
Sex/Gender
All
Age
3 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1) Age between 3-6y, gender is not limited; 2) Children planning to undergo general anesthesia with laryngeal mask, ASA anesthesia grade I-II; 3) Children who choose to undergo laparoscopic hernia surgery, laparoscopic testicular fixation surgery, or laparoscopic high ligation of the sheath process; 4) The parents or legal guardians of the affected child have signed an informed consent form for medical research.
Exclusion criteria
Exclusion criteria: 1) Children with allergies to ketamine and its components; Children with severe thrombocytopenia and gastrointestinal ulcers. 2) Analgesics, sedatives, antiemetics, and antipruritic drugs were used 24 hours before surgery; 3) Children with symptoms of acute upper respiratory tract infection before surgery; 4) Children with a history of bronchial asthma; 5) Children with severe sleep apnea syndrome and arrhythmia; 6) Has a history of abnormal surgical anesthesia recovery in the past; Preoperative assessment of the presence or possibility of difficult airway conditions 7) Renal dysfunction (BUN and/or Cr>upper limit of normal value); Liver function damage (ALT and/or AST>1.5 times the upper limit of normal values); 8) Children who are deemed unsuitable for inclusion by researchers due to other circumstances.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to stop inhaling sevoflurane;trachea canula extubated time; | — |
Secondary
| Measure | Time frame |
|---|---|
| BIS value when stopping inhalation of sevoflurane;Body movement time;Eye opening time;Times with BIS values of 70 respectively;Time with BIS values of 80 respectively;Time with BIS values of 90 respectively; | — |
Countries
China
Contacts
Public ContactNa Zhang
Guangzhou Women and Children's Medical Centre
Outcome results
None listed